ipamorelin
GH AXIS · GHS-R1a AGONIST · 5 AA · T½ ~2 H
also: NNC 26-0161 · ipamorelin acetate
Ipamorelin is a pentapeptide agonist of the ghrelin receptor (GHS-R1a) reported as the first growth hormone secretagogue with GH selectivity comparable to GHRH itself, without the ACTH and cortisol release seen with earlier GHRPs. Its clinical development was discontinued after a phase 2 trial in postoperative ileus failed to meet its primary endpoint, and FDA has stated it has not identified data supporting effectiveness for any proposed use.
// our evidence grade — unedited
Its selectivity for GH release without ACTH, cortisol or prolactin elevation is genuinely well demonstrated in preclinical work, but the only published human efficacy trial missed its primary endpoint and no phase 3 efficacy data exist for any indication.
We grade this compound and we sell it. The grade is set against our published criteria before any stocking decision and is not adjusted because it is in the catalogue.
read the full evidence →// specification
| full name | Aib-His-D-2-Nal-D-Phe-Lys-NH2, a selective growth hormone secretagogue receptor agonist |
| cas | 170851-70-4 |
| formula | C38H49N9O5 |
| molar mass | 711.87 g/mol |
| purity | ≥ 99% HPLC |
| form | lyophilised powder, sealed vial |
| storage | Ipamorelin acetate lyophilised powder is reported stable up to 4 years at -20°C with 2-8°C storage recommended for shorter periods; the free base is stable roughly 3 weeks at room temperature when desiccated, with storage below -18°C recommended. Reconstituted solution is held at 2-8°C, protected from light, and not refrozen. |
| solubility | The acetate salt dissolves in water at about 5 mg/mL and is the form used in laboratory settings, typically reconstituted with bacteriostatic or sterile water; the free base is effectively insoluble in water at 0.0032 mg/mL and requires organic solvent. |
| sequence | Aib-His-D-2-Nal-D-Phe-Lys-NH2 |
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crypto payment · research use only · not for human consumption
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