hexarelin
GH AXIS · GHS-R1a AGONIST · 6 AA · TACHYPHYLAXIS
also: examorelin · EP-23905 · MF-6003
Hexarelin is a synthetic hexapeptide agonist of the ghrelin receptor (GHS-R1a) that acutely raises growth hormone along with prolactin, ACTH and cortisol. It reached phase 2 trials for growth hormone deficiency and congestive heart failure but was never marketed, and controlled studies show the GH response desensitises substantially with continued administration.
// our evidence grade — unedited
It has more long-term human data than most compounds here, and that data is unfavourable: the GH response attenuates progressively over 16 weeks and IGF-1 did not change at all across 20 weeks of treatment.
We grade this compound and we sell it. The grade is set against our published criteria before any stocking decision and is not adjusted because it is in the catalogue.
read the full evidence →// specification
| full name | His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2, a synthetic growth hormone-releasing hexapeptide |
| cas | 140703-51-1 |
| formula | C47H58N12O6 |
| molar mass | 887.05 g/mol |
| purity | ≥ 99% HPLC |
| form | lyophilised powder, sealed vial |
| storage | Lyophilised hexarelin is stored at -20°C, desiccated and protected from light, for long-term laboratory storage. Reconstituted solution is held at 2-8°C for short-term use and aliquoted before freezing to avoid repeated freeze-thaw cycles. |
| solubility | Reported laboratory solubility is approximately 10 mg/mL in PBS pH 7.2, 30 mg/mL in DMSO or DMF and 5 mg/mL in ethanol; aqueous buffer or bacteriostatic water is the usual reconstitution solvent. |
| sequence | His-D-2-Me-Trp-Ala-Trp-D-Phe-Lys-NH2 |
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crypto payment · research use only · not for human consumption
// others in Growth Hormone