cjc-1295 with dac
GH AXIS · GHRH-R AGONIST · 30 AA + DAC · T½ ~6-8 D
also: CJC-1295 DAC · DAC:GRF · CJC-1295 with drug affinity complex
CJC-1295 with DAC is a tetrasubstituted GHRH(1-29) analogue bearing a maleimidopropionyl group that covalently binds circulating albumin, extending its half-life to roughly a week. Two randomised placebo-controlled trials in healthy adults showed sustained GH and IGF-1 elevation, but development was discontinued in 2006 after a death in a phase 2 trial and no efficacy trial in any disease has been published.
// our evidence grade — unedited
It has genuine published human randomised pharmacodynamic data and by far the longest half-life in this group, but no trial has ever administered it to patients with a disease, and the only phase 2 programme was terminated after a participant death.
We grade this compound and we sell it. The grade is set against our published criteria before any stocking decision and is not adjusted because it is in the catalogue.
read the full evidence →// specification
| full name | Nε30-maleimidopropionyl-[D-Ala2, Gln8, Ala15, Leu27]-GRF(1-29)-Lys30 amide, drug affinity complex form |
| cas | 446262-90-4 |
| formula | C165H269N47O46 |
| molar mass | 3647.95 g/mol |
| purity | ≥ 99% HPLC |
| form | lyophilised powder, sealed vial |
| storage | Lyophilised peptide is stored desiccated at -20°C or below and protected from light for long-term laboratory storage; short-term storage at 2-8°C is used for material in active use. Reconstituted solution is held at 2-8°C and not subjected to repeated freeze-thaw cycles. |
| solubility | Reconstituted with bacteriostatic or sterile water in laboratory settings; the maleimide group is moisture- and thiol-sensitive, so solutions are prepared fresh and not stored at room temperature. |
| sequence | Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-Lys(Nε-maleimidopropionyl)-NH2 |
// select size
crypto payment · research use only · not for human consumption
// others in Growth Hormone