aod-9604
METABOLIC · hGH C-TERMINAL FRAGMENT · 16 AA · DISULFIDE-CYCLISED
also: AOD9604 · AOD-9604 · hGH fragment 176-191
AOD9604 is a 16-amino-acid analogue of the C-terminal lipolytic domain of human growth hormone, developed as an oral anti-obesity agent and taken through six randomised placebo-controlled trials totalling around 893 adults. It was consistently well tolerated and did not affect IGF-1 or carbohydrate metabolism, but a 12-week signal of roughly 2.6 kg versus 0.8 kg on placebo failed to replicate in a subsequent 24-week study and development was terminated in 2007.
// our evidence grade — unedited
AOD9604 is unusual among low-tier compounds in having genuine randomised human data — roughly 900 subjects across six placebo-controlled trials — and that data is what condemns it: the modest 12-week signal did not survive a longer confirmatory trial, development was terminated in 2007, and everything since has been repositioning rather than new efficacy evidence.
We grade this compound and we sell it. The grade is set against our published criteria before any stocking decision and is not adjusted because it is in the catalogue.
read the full evidence →// specification
| full name | AOD9604 (Tyr-hGH177-191, human growth hormone C-terminal fragment 176-191 analogue) |
| cas | 221231-10-3 |
| formula | C78H123N23O23S2 |
| molar mass | 1815.1 g/mol |
| purity | ≥ 99% HPLC |
| form | lyophilised powder, sealed vial |
| storage | Lyophilised peptide is stored at -20 °C, desiccated and protected from light; reconstituted solution is held at 2-8 °C for short-term laboratory use or frozen in single-use aliquots, with freeze-thaw cycles avoided because of the internal disulfide bond. |
| solubility | Soluble in sterile or bacteriostatic water and aqueous buffers; laboratory stocks are commonly prepared in water or dilute acetic acid, with care taken to avoid reducing agents that would cleave the Cys7-Cys14 bridge. |
| sequence | YLRIVQCRSVEGSCGF (Cys7-Cys14 disulfide bridge; N-terminal Tyr substituted for Phe) |
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crypto payment · research use only · not for human consumption
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