adipotide
PROAPOPTOTIC PEPTIDOMIMETIC · PROHIBITIN-TARGETED · RENAL SIGNAL · ABANDONED
also: FTPP · fat-targeted proapoptotic peptide · prohibitin-targeting peptide-1
Adipotide is a synthetic chimeric peptidomimetic developed at MD Anderson that links a nine-residue motif homing to prohibitin on white adipose tissue vasculature to a D-amino-acid amphipathic sequence that disrupts mitochondrial membranes. In obese rhesus monkeys it produced rapid weight loss and improved insulin sensitivity, and in the same experiments monkeys of three species showed changes in renal proximal tubule function. A first-in-human phase 1 trial in men with metastatic prostate cancer and obesity began in 2012 but was terminated with four patients enrolled and no results have ever been reported.
// our evidence grade — unedited
The primate study that made adipotide famous reported, in the same abstract as the weight loss, that monkeys of three different species showed changes in renal proximal tubule function; the only human trial ever registered (NCT01262664) was terminated with 4 participants enrolled against a planned 15 and has never posted results. A documented target-organ toxicity plus an abandoned first-in-human trial with no published outcome is the bottom of the scale.
We grade this compound and we sell it. The grade is set against our published criteria before any stocking decision and is not adjusted because it is in the catalogue.
read the full evidence →// specification
| full name | Adipotide, the prohibitin-targeting proapoptotic peptidomimetic CKGGRAKDC-GG-D(KLAKLAK)2 |
| cas | 859216-15-2 |
| formula | C111H206N36O28S2 |
| molar mass | 2557.2 g/mol |
| purity | ≥ 98% HPLC |
| form | lyophilised powder, sealed vial |
| storage | Lyophilised powder is stored desiccated at -20 °C and protected from light. Once reconstituted, laboratory practice is refrigeration at 2-8 °C for short-term use, or aliquoting and freezing to avoid repeated freeze-thaw cycles. Handling information only; this material has no approved human use. |
| solubility | Short hydrophilic peptide, readily soluble in sterile or bacteriostatic water and in dilute aqueous buffer. Lot-specific solubility is stated on the certificate of analysis. |
| sequence | CKGGRAKDC-GG-D(KLAKLAK)2 (25 residues; a disulfide-cyclised CKGGRAKDC prohibitin-homing motif joined by a Gly-Gly linker to a tandem D-amino-acid amphipathic KLAKLAK mitochondria-disrupting module; the formula and mass recorded below are PubChem's, which correspond to the reduced, non-cyclised form and differ from the cyclised peptide by two hydrogens) |
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crypto payment · research use only · not for human consumption
// others in Metabolic