aicar
METABOLIC · AMPK ACTIVATOR · INJECTABLE · PROHIBITED IN SPORT · PRECLINICAL FOR PERFORMANCE
also: acadesine · AICA riboside · AICA-riboside
AICAR is a cell-permeable AMP analogue that activates AMP-activated protein kinase and produced a well-known increase in running endurance in sedentary mice. For athletic or body-composition purposes the evidence remains essentially preclinical; the largest human randomised trial tested it for cardioprotection during bypass surgery and was stopped early for futility.
// our evidence grade — unedited
The famous endurance result is a single 2008 mouse experiment at 500 mg/kg/day by injection, the one large human randomised trial was for cardiac surgery and stopped for futility, and it is prohibited in sport at all times with no approved therapeutic use anywhere.
We grade this compound and we sell it. The grade is set against our published criteria before any stocking decision and is not adjusted because it is in the catalogue.
read the full evidence →// specification
| full name | AICAR (acadesine, 5-aminoimidazole-4-carboxamide riboside) |
| cas | 2627-69-2 |
| formula | C9H14N4O5 |
| molar mass | 258.2 g/mol |
| purity | ≥ 98% HPLC |
| form | lyophilised powder, sealed vial |
| storage | Solid stored at -20 °C per supplier specification; solutions prepared fresh or stored frozen. |
| solubility | Water-soluble relative to the other compounds in this index. Cayman Chemical reports DMSO 20 mg/mL, DMF 10 mg/mL, PBS pH 7.2 2 mg/mL, and ethanol 1 mg/mL. |
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crypto payment · research use only · not for human consumption
// others in Metabolic