5-amino-1mq
METABOLIC · NNMT INHIBITOR · SMALL MOLECULE · NOT A PEPTIDE
also: 5-Amino-1MQ · 5A1MQ · 5-amino-1-methylquinolinium iodide
5-Amino-1MQ is a small-molecule, membrane-permeable inhibitor of nicotinamide N-methyltransferase (NNMT) — not a peptide, despite being sold alongside them. In diet-induced obese mice it reduced body weight and white adipose mass without changing food intake, but no human pharmacokinetic, safety or efficacy study has been published.
// our evidence grade — unedited
The mouse data are real, internally consistent and replicated across at least three publications from the same group, but there is not a single human study of any kind, the pivotal experiments used injected doses in the 34-40 mg/kg/day range while the product is sold as oral capsules, and the target enzyme has substantial roles in cancer biology that no one has mapped for chronic systemic inhibition in people.
We grade this compound and we sell it. The grade is set against our published criteria before any stocking decision and is not adjusted because it is in the catalogue.
read the full evidence →// specification
| full name | 5-amino-1-methylquinolinium (commonly supplied as the iodide salt) |
| cas | 42464-96-0 |
| formula | C10H11IN2 (iodide salt); C10H11N2+ cation |
| molar mass | 286.11 g/mol |
| purity | ≥ 98% HPLC |
| form | research solution |
| storage | Solid material is stored at -20 °C, desiccated and protected from light, in a tightly sealed container; solutions in aqueous buffer or DMSO are aliquoted and stored at -20 °C to -80 °C for laboratory use and protected from light, with repeated freeze-thaw cycles avoided. |
| solubility | As a quaternary quinolinium salt it is water-soluble and dissolves readily in aqueous buffers and saline; DMSO is used for concentrated laboratory stock solutions, which are then diluted into aqueous media. |
// select size
crypto payment · research use only · not for human consumption
// others in Metabolic