vilon
LYS-GLU DIPEPTIDE · 2 AA · KHAVINSON BIOREGULATOR · NO REGISTERED TRIALS
also: KE dipeptide · Lys-Glu · L-Lys-L-Glu
Vilon is the dipeptide Lys-Glu, synthesised by Khavinson's group as a defined analogue of the activity they attribute to the thymus extract Thymalin, and now sold as a general immune and ‘geroprotective’ bioregulator. Its evidence base is preclinical: mouse lifespan and spontaneous-tumour studies, inhibition of chemically induced rat bladder tumours, effects on intestinal absorption and liver regeneration, and reactivation of condensed chromatin in lymphocytes from elderly donors. Human reports exist but are confined to two small Russian-language papers in Advances in Gerontology, and no trial of Vilon has ever been registered.
// our evidence grade — unedited
Vilon has a substantial literature for a two-residue peptide — around 80 PubMed records, mouse lifespan and tumour-incidence experiments, and chromatin-decondensation work partly replicated by a Georgian cytogenetics group without Khavinson co-authorship — but ClinicalTrials.gov has no registered study of it, and its human evidence amounts to two small uncontrolled Russian reports in the originating group's own gerontology journal. The lifespan and geroprotection claims outrun that data by a wide margin.
We grade this compound and we sell it. The grade is set against our published criteria before any stocking decision and is not adjusted because it is in the catalogue.
read the full evidence →// specification
| full name | Vilon (L-lysyl-L-glutamic acid, Lys-Glu) |
| cas | 45234-02-4 |
| formula | C11H21N3O5 |
| molar mass | 275.3 g/mol |
| purity | ≥ 98% HPLC |
| form | lyophilised powder, sealed vial |
| storage | Lyophilised powder is stored desiccated at -20 °C and protected from light. Once reconstituted, laboratory practice is refrigeration at 2-8 °C for short-term use, or aliquoting and freezing to avoid repeated freeze-thaw cycles. Handling information only; this material has no approved human use. |
| solubility | Short hydrophilic peptide, readily soluble in sterile or bacteriostatic water and in dilute aqueous buffer. Lot-specific solubility is stated on the certificate of analysis. |
| sequence | Lys-Glu (KE) |
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crypto payment · research use only · not for human consumption
// others in Longevity