epitalon
LONGEVITY · PINEAL TETRAPEPTIDE · 4 AA
also: Epithalon · Epithalamin (the related pineal extract) · AEDG peptide
Epitalon is a synthetic tetrapeptide modelled on epithalamin, a pineal gland extract developed by Vladimir Khavinson's group in St Petersburg, and is claimed to activate telomerase and act as a geroprotector. Reported effects include telomere elongation in cultured human fibroblasts and modest maximum-lifespan extension in mice, but essentially all of this work originates from one research group and has not been independently replicated.
// our evidence grade — unedited
Every substantive lifespan and telomerase claim traces to a single St Petersburg research group publishing in Russian journals, with no Western replication in the two decades since, and the strongest reported effect was on maximum rather than mean lifespan.
We grade this compound and we sell it. The grade is set against our published criteria before any stocking decision and is not adjusted because it is in the catalogue.
read the full evidence →// specification
| full name | Alanyl-glutamyl-aspartyl-glycine (AEDG tetrapeptide) |
| cas | 307297-39-8 |
| formula | C14H22N4O9 |
| molar mass | 390.35 g/mol |
| purity | ≥ 99% HPLC |
| form | lyophilised powder, sealed vial |
| storage | Lyophilised powder stable at -20°C protected from light and moisture; after reconstitution store at 2-8°C and use within approximately 2-4 weeks, avoiding repeated freeze-thaw cycles. |
| solubility | Freely soluble in sterile or bacteriostatic water; the short, highly polar tetrapeptide dissolves readily in aqueous buffer. |
| sequence | Ala-Glu-Asp-Gly |
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crypto payment · research use only · not for human consumption
// others in Longevity