thymagen
GLU-TRP DIPEPTIDE · 2 AA · REGISTERED IN RUSSIA · FAILED PHASE 3 AS IM-862
also: Thymogen · Timogen · Тимоген
Thymagen, more usually Thymogen, is the dipeptide L-glutamyl-L-tryptophan, isolated from thymus extract in Leningrad in the 1980s and registered in Russia as an immunomodulator in injectable, nasal-spray, topical and oral forms under the international name alpha-glutamyl-tryptophan. The identical molecule was licensed into Western development as oglufanide disodium (IM-862), received FDA orphan-drug designation for ovarian cancer in 2001, reached phase 3 in AIDS-related Kaposi's sarcoma and was found ineffective, after which development was abandoned. The peptide sold to researchers as ‘Thymagen’ is therefore the best-tested compound in the Khavinson family and also the one with the clearest negative result.
// our evidence grade — unedited
Uniquely in this family, the same molecule was developed in the West as oglufanide disodium / IM-862 and tested in registered trials — and it failed: a phase 3 study concluded IM-862 ‘is ineffective against AIDS-Kaposi's sarcoma’ after phase 1/2 had suggested a 36 percent response rate, and a phase 2 in metastatic renal cell carcinoma produced no objective responses in 25 evaluable patients. That is a defining trial that failed, on top of which none of the organ-specific epigenetic or geroprotective bioregulator claims has ever been tested in humans.
We grade this compound and we sell it. The grade is set against our published criteria before any stocking decision and is not adjusted because it is in the catalogue.
read the full evidence →// specification
| full name | Thymagen / Thymogen (L-glutamyl-L-tryptophan, Glu-Trp) |
| cas | 38101-59-6 |
| formula | C16H19N3O5 |
| molar mass | 333.34 g/mol |
| purity | ≥ 98% HPLC |
| form | lyophilised powder, sealed vial |
| storage | Lyophilised powder is stored desiccated at -20 °C and protected from light. Once reconstituted, laboratory practice is refrigeration at 2-8 °C for short-term use, or aliquoting and freezing to avoid repeated freeze-thaw cycles. Handling information only; this material has no approved human use. |
| solubility | Short hydrophilic peptide, readily soluble in sterile or bacteriostatic water and in dilute aqueous buffer. Lot-specific solubility is stated on the certificate of analysis. |
| sequence | Glu-Trp (EW) |
// select size
crypto payment · research use only · not for human consumption
// others in Other