hep-1
EZRIN FRAGMENT · IMMUNOMODULATOR · RUSSIA-ONLY REGISTRATION · 14 AA
also: Gepon · Hepon · Гепон
HEP-1, marketed in Russia as Gepon, is a synthetic 14-residue peptide corresponding to a sequence within human ezrin, registered in the Russian Federation as an immunomodulator for infections and immunodeficiency states. The registration is real and verifiable, but the supporting clinical evidence is almost entirely Russian and is authored by the peptide's own developers, one of whom operates a commercial company built around it. Outside Russia the compound has produced one registered phase 1 trial that appears never to have reported, and no independent replication.
// our evidence grade — unedited
The Russian registration is genuine — Gepon is listed as an immunostimulant (ATC L03AX) with a Russian marketing authorisation and a named manufacturer — but essentially the entire clinical literature in any language is authored by the two people who developed and commercialise it, and ClinicalTrials.gov holds a single registration (NCT04627233, Iran, 20 participants planned) that never posted a status update after November 2020 or any results. That is thinner than Semax or Selank, both graded C on Russian-only evidence.
We grade this compound and we sell it. The grade is set against our published criteria before any stocking decision and is not adjusted because it is in the catalogue.
read the full evidence →// specification
| full name | HEP-1 (human ezrin peptide one), the synthetic tetradecapeptide TEKKRRETVEREKE marketed in Russia as Gepon |
| cas | 174641-44-2 |
| formula | C74H132N26O27 |
| molar mass | 1818 g/mol |
| purity | ≥ 98% HPLC |
| form | lyophilised powder, sealed vial |
| storage | Lyophilised powder is stored desiccated at -20 °C and protected from light. Once reconstituted, laboratory practice is refrigeration at 2-8 °C for short-term use, or aliquoting and freezing to avoid repeated freeze-thaw cycles. Handling information only; this material has no approved human use. |
| solubility | Short hydrophilic peptide, readily soluble in sterile or bacteriostatic water and in dilute aqueous buffer. Lot-specific solubility is stated on the certificate of analysis. |
| sequence | TEKKRRETVEREKE (14 aa; a sequence found within the alpha-helical domain of human ezrin, UniProt P15311) |
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crypto payment · research use only · not for human consumption
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