snap-8
COSMETIC INGREDIENT · SNAP-25 FRAGMENT · TOPICAL NEUROMUSCULAR CLAIM
also: SNAP-8 · acetyl octapeptide-3 · acetyl glutamyl heptapeptide-1
SNAP-8 is an octapeptide corresponding to a fragment of SNAP-25, the SNARE protein required for acetylcholine vesicle fusion, acetylated at the N-terminus and amidated at the C-terminus. It carries the INCI name Acetyl Octapeptide-3 (also encountered as acetyl glutamyl heptapeptide-1) and was introduced by Lipotec as a topical alternative to botulinum toxin, extending the shorter and better-studied Argireline sequence by two residues. Its efficacy record consists of supplier in-house profilometry rather than peer-reviewed trials.
// our evidence grade — unedited
The famous 63% figure is a maximum, not a mean, from an unpublished supplier in-house study in 17 women over 28 days, and no peer-reviewed trial has ever tested acetyl octapeptide-3 as a single active - the only two published human studies containing it are multi-ingredient microneedle patches. ClinicalTrials.gov returns zero registered studies, and the "topical botox" framing rests on a SNARE-competition mechanism never demonstrated in human skin.
We grade this compound and we sell it. The grade is set against our published criteria before any stocking decision and is not adjusted because it is in the catalogue.
read the full evidence →// specification
| full name | Acetyl octapeptide-3 (Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2), an N-acetylated, C-amidated octapeptide fragment of SNAP-25 |
| cas | 868844-74-0 |
| formula | C41H70N16O16S |
| molar mass | 1075.2 g/mol |
| purity | ≥ 98% HPLC |
| form | lyophilised powder, sealed vial |
| storage | Lyophilised powder is stored desiccated at -20 °C and protected from light. Once reconstituted, laboratory practice is refrigeration at 2-8 °C for short-term use, or aliquoting and freezing to avoid repeated freeze-thaw cycles. Handling information only; this material has no approved human use. |
| solubility | Short hydrophilic peptide, readily soluble in sterile or bacteriostatic water and in dilute aqueous buffer. Lot-specific solubility is stated on the certificate of analysis. |
| sequence | Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2 |
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crypto payment · research use only · not for human consumption
// others in Cosmetic