matrixyl
COSMETIC INGREDIENT · PROCOLLAGEN MATRIKINE · LIPOPEPTIDE · TOPICAL EVIDENCE ONLY
also: palmitoyl pentapeptide-4 · pal-KTTKS · palmitoyl pentapeptide-3
Palmitoyl pentapeptide-4 is a synthetic lipopeptide in which the collagen-derived pentapeptide KTTKS is joined to a palmitic acid tail. It carries the INCI name Palmitoyl Pentapeptide-4, has been sold as the Sederma/Croda cosmetic active Matrixyl since the late 1990s, and is lawfully used in leave-on skincare across the UK and EU. KTTKS itself is a genuine fragment of the C-terminal propeptide of type I procollagen that stimulates collagen and fibronectin production in cultured mesenchymal cells.
// our evidence grade — unedited
Two double-blind placebo-controlled topical trials exist and they disagree: a 93-subject 12-week study run by the ingredient's commercial developer reported significant fine-line improvement, while the only independent replication (21 women, seven per arm, 8 weeks) found every instrumental endpoint non-significant (p>0.05) and no separation from placebo. Real matrikine mechanism, thin and inconsistent human data, and zero registered trials on ClinicalTrials.gov.
We grade this compound and we sell it. The grade is set against our published criteria before any stocking decision and is not adjusted because it is in the catalogue.
read the full evidence →// specification
| full name | Palmitoyl pentapeptide-4 (palmitoyl-Lys-Thr-Thr-Lys-Ser, pal-KTTKS), the cosmetic active trademarked as Matrixyl |
| cas | 214047-00-4 |
| formula | C39H75N7O10 |
| molar mass | 802.1 g/mol |
| purity | ≥ 98% HPLC |
| form | lyophilised powder, sealed vial |
| storage | Lyophilised powder is stored desiccated at -20 °C, protected from light and moisture. Palmitoylated peptides are surface-active and prone to adsorption losses, so laboratory preparations are handled in low-binding vessels. Handling information only. |
| solubility | Amphiphilic: poorly soluble in water alone, and laboratory preparations typically use a small proportion of a co-solvent before dilution into aqueous buffer. |
| sequence | Palmitoyl-Lys-Thr-Thr-Lys-Ser |
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crypto payment · research use only · not for human consumption
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