pinealon
TRIPEPTIDE · KHAVINSON BRAIN BIOREGULATOR · EDR · OPEN-LABEL HUMAN SERIES ONLY
also: EDR · Glu-Asp-Arg · H-Glu-Asp-Arg-OH
Pinealon is the best-documented compound of this group: a verified tripeptide, Glu-Asp-Arg, with a PubChem record and a CAS number, and 22 PubMed-indexed publications. The biology is nonetheless preclinical — reactive oxygen species suppression in cultured cells, dendritic spine preservation in 5xFAD Alzheimer's model mice, hypoxia and behaviour experiments in aged rats, and biophysical characterisation of EDR binding in the DNA major groove. Human use is supported only by open-label series in Russian-language gerontology journals, with no randomised or placebo-controlled trial and no trial registration.
// our evidence grade — unedited
Pinealon has the largest literature of the five — 22 PubMed-indexed papers — yet zero registered trials on ClinicalTrials.gov and no randomised or placebo-controlled human study anywhere; the human evidence is an open adjunct series of 72 patients described only inside the group's own review plus an uncontrolled 32-patient observation that itself reported prooxidant activity.
We grade this compound and we sell it. The grade is set against our published criteria before any stocking decision and is not adjusted because it is in the catalogue.
read the full evidence →// specification
| full name | Pinealon (L-glutamyl-L-aspartyl-L-arginine; Glu-Asp-Arg, EDR) |
| cas | 175175-23-2 |
| formula | C15H26N6O8 |
| molar mass | 418.4 g/mol |
| purity | ≥ 98% HPLC |
| form | lyophilised powder, sealed vial |
| storage | Lyophilised powder is stored desiccated at -20 °C and protected from light. Once reconstituted, laboratory practice is refrigeration at 2-8 °C for short-term use, or aliquoting and freezing to avoid repeated freeze-thaw cycles. Handling information only; this material has no approved human use. |
| solubility | Short hydrophilic peptide, readily soluble in sterile or bacteriostatic water and in dilute aqueous buffer. Lot-specific solubility is stated on the certificate of analysis. |
| sequence | Glu-Asp-Arg (EDR) |
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crypto payment · research use only · not for human consumption
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