dnsp-11
GDNF PROPEPTIDE · DOPAMINERGIC NEUROTROPHIC · PRECLINICAL ONLY
also: DNSP-11 · DNSP11 · Dopamine Neuron Stimulating Peptide-11
DNSP-11 is an 11-amino-acid amidated peptide (PPEAPAEDRSL-amide) predicted to be endoproteolytically cleaved from the pro-domain of proGDNF, the precursor of glial cell line-derived neurotrophic factor. It was described and developed at the University of Kentucky by Bradley, Gash and Gerhardt, and in rodent and non-human-primate work it increased striatal dopamine turnover, spared tyrosine-hydroxylase-positive neurons and reduced rotational asymmetry in 6-OHDA-lesioned rats. There is no human data of any kind: no registered clinical trial, no published pharmacokinetics, and no regulatory approval anywhere.
// our evidence grade — unedited
DNSP-11 has never been given to a human being: a ClinicalTrials.gov search returns zero registered studies, and the entire literature is roughly six preclinical papers from a single University of Kentucky group. The clinical record invoked to support it belongs to the parent protein GDNF, whose only proper randomised trial missed its primary endpoint (p=0.41) and whose commercial development was halted in 2004 over preclinical irreversible brain damage.
We grade this compound and we sell it. The grade is set against our published criteria before any stocking decision and is not adjusted because it is in the catalogue.
read the full evidence →// specification
| full name | Dopamine Neuron Stimulating Peptide-11 |
| formula | C50H81N15O18 |
| molar mass | 1180.27 g/mol |
| purity | ≥ 98% HPLC |
| form | lyophilised powder, sealed vial |
| storage | Supplied as the trifluoroacetate salt and stored desiccated at -20 °C, protected from light. Reconstituted solution is aliquoted and frozen. Handling information only. |
| solubility | Soluble in sterile water and aqueous buffer. Residual trifluoroacetate from synthesis is normal for this material and is reported on the certificate of analysis. |
| sequence | Pro-Pro-Glu-Ala-Pro-Ala-Glu-Asp-Arg-Ser-Leu-NH2 (PPEAPAEDRSL-amide; C-terminally amidated) |
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crypto payment · research use only · not for human consumption
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