pe-22-28
SORTILIN PROPEPTIDE FRAGMENT · TREK-1 MODULATOR · SPADIN ANALOGUE · PRECLINICAL ONLY
also: PE 22-28 · PE22-28 · mini-spadin
PE 22-28 is a seven-residue fragment (GVSWGLR) of the propeptide released when the sortilin precursor is cleaved by furin, identified in 2017 as the shortest and most potent of a series of truncations of spadin, the 17-residue peptide PE 12-28. In mouse work from the CNRS Institut de Pharmacologie Moléculaire et Cellulaire in Nice it is reported to inhibit TREK-1 potassium channels roughly 300-fold more potently than spadin, and produces antidepressant-like behaviour within days together with increased hippocampal neurogenesis. It has never been given to a human, has no registered clinical trial, and is not an approved medicine anywhere.
// our evidence grade — unedited
ClinicalTrials.gov returns zero registered studies for PE 22-28 and zero for spadin, its parent, so neither molecule has ever entered a registered human trial despite the originating group writing in 2018 that clinical use was 'currently in progress'. The compound's defining claim — potent TREK-1 blockade — was contradicted by the only independent electrophysiology study, in which spadin produced no reduction at all in basal mouse TREK-1 current, the currents recorded with and without it being indistinguishable.
We grade this compound and we sell it. The grade is set against our published criteria before any stocking decision and is not adjusted because it is in the catalogue.
read the full evidence →// specification
| full name | PE 22-28 (mini-spadin), the heptapeptide Gly-Val-Ser-Trp-Gly-Leu-Arg corresponding to residues 22-28 of the human sortilin/NTSR3 propeptide |
| cas | 1801959-12-5 |
| formula | C35H55N11O9 |
| molar mass | 773.89 g/mol |
| purity | ≥ 98% HPLC |
| form | lyophilised powder, sealed vial |
| storage | Lyophilised powder is stored desiccated at -20 °C and protected from light. Once reconstituted, laboratory practice is refrigeration at 2-8 °C for short-term use, or aliquoting and freezing to avoid repeated freeze-thaw cycles. Handling information only; this material has no approved human use. |
| solubility | Short hydrophilic peptide, readily soluble in sterile or bacteriostatic water and in dilute aqueous buffer. Lot-specific solubility is stated on the certificate of analysis. |
| sequence | Gly-Val-Ser-Trp-Gly-Leu-Arg (GVSWGLR) — propeptide residues 22-28 of human sortilin/NTSR3, corresponding to residues 55-61 of UniProt Q99523. The parent peptide spadin is PE 12-28, APLPRWSGPIGVSWGLR. |
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crypto payment · research use only · not for human consumption
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