pal-ghk
COSMETIC INGREDIENT · PALMITOYLATED GHK · MATRIKINE · BORROWED EVIDENCE
also: palmitoyl tripeptide-1 · PAL-GHK · Pal-Gly-His-Lys
Palmitoyl tripeptide-1 is the tripeptide glycyl-histidyl-lysine with a palmitic acid chain attached to the N-terminal glycine, sold under the INCI name Palmitoyl Tripeptide-1 and, historically, under the broader label palmitoyl oligopeptide. It is one of the two actives in Sederma's Matrixyl 3000 (with palmitoyl tetrapeptide-7) and is used in leave-on skincare across the UK and EU. Unlike its parent tripeptide's copper complex, the palmitoylated free peptide has essentially no published clinical trial of its own.
// our evidence grade — unedited
A 2024 review of topically applied GHK states there is a "surprising absence of clinical studies" for both GHK-Cu and Pal-GHK, and the only human data traceable for palmitoyl tripeptide-1 is a 15-subject supplier study cited second-hand in a Cosmetic Ingredient Review literature review; ClinicalTrials.gov returns zero registered trials. The regenerative and wound-healing literature routinely quoted for it belongs to the copper complex GHK-Cu, a different molecule.
We grade this compound and we sell it. The grade is set against our published criteria before any stocking decision and is not adjusted because it is in the catalogue.
read the full evidence →// specification
| full name | Palmitoyl tripeptide-1 (palmitoyl-Gly-His-Lys, Pal-GHK) |
| cas | 147732-56-7 |
| formula | C30H54N6O5 |
| molar mass | 578.8 g/mol |
| purity | ≥ 98% HPLC |
| form | lyophilised powder, sealed vial |
| storage | Lyophilised powder is stored desiccated at -20 °C, protected from light and moisture. Palmitoylated peptides are surface-active and prone to adsorption losses, so laboratory preparations are handled in low-binding vessels. Handling information only. |
| solubility | Amphiphilic: poorly soluble in water alone, and laboratory preparations typically use a small proportion of a co-solvent before dilution into aqueous buffer. |
| sequence | Palmitoyl-Gly-His-Lys |
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crypto payment · research use only · not for human consumption
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