orexin-b
ENDOGENOUS NEUROPEPTIDE · OX2R-PREFERRING · 28 AA · NO HUMAN DATA
also: hypocretin-2 · hcrt-2 · OX-B
Orexin B is the shorter of the two neuropeptides cleaved from prepro-orexin, acting as a full agonist at the OX2 receptor and a weaker agonist at OX1. It shares the arousal-regulating biology of orexin A but has been studied far less, and unlike orexin A it has never been given to humans in any published study. Its physical chemistry is also less favourable: it lacks the lipophilicity of orexin A and is degraded quickly in blood.
// our evidence grade — unedited
There is no published study in which orexin B has been administered to a human being, and ClinicalTrials.gov holds zero registered studies of it; the sibling peptide orexin A has at least three small intranasal studies, so orexin B has strictly less human evidence than a compound already graded low. Radiolabelling work in mice found no intact orexin B in brain after peripheral injection because it is rapidly degraded in blood.
We grade this compound and we sell it. The grade is set against our published criteria before any stocking decision and is not adjusted because it is in the catalogue.
read the full evidence →// specification
| full name | Orexin B (hypocretin-2), the 28-residue amidated neuropeptide processed from human prepro-orexin (HCRT) |
| cas | 205599-76-4 |
| formula | C123H212N44O35S |
| molar mass | 2899.3 g/mol |
| purity | ≥ 98% HPLC |
| form | lyophilised powder, sealed vial |
| storage | Lyophilised powder is stored desiccated at -20 °C and protected from light. Once reconstituted, laboratory practice is refrigeration at 2-8 °C for short-term use, or aliquoting and freezing to avoid repeated freeze-thaw cycles. Handling information only; this material has no approved human use. |
| solubility | Short hydrophilic peptide, readily soluble in sterile or bacteriostatic water and in dilute aqueous buffer. Lot-specific solubility is stated on the certificate of analysis. |
| sequence | RSGPPGLQGRLQRLLQASGNHAAGILTM-NH2 (28 aa; C-terminal methioninamide, no disulfide bonds; residues 70–97 of human prepro-orexin, UniProt O43612) |
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crypto payment · research use only · not for human consumption
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