orexin-a
ENDOGENOUS NEUROPEPTIDE · OX1R/OX2R AGONIST · 33 AA · UNAPPROVED
also: hypocretin-1 · hcrt-1 · OX-A
Orexin A is an endogenous hypothalamic neuropeptide that, with orexin B, maintains arousal and stabilises the boundary between wake and REM sleep by activating the OX1 and OX2 receptors. Its deficiency is the established cause of narcolepsy type 1, which makes it one of the best-characterised neuropeptides in human medicine. Administering the peptide itself is a completely different proposition from understanding it, and the human administration literature amounts to three small intranasal crossover studies in narcolepsy.
// our evidence grade — unedited
The biology is world-class but the peptide as an administered drug is not: exactly three published human studies exist, all intranasal, all from one German group, with 29 people in total ever exposed, and the one that measured wakefulness in narcolepsy found no significant increase in wakefulness. ClinicalTrials.gov holds zero registered studies in which orexin-A itself is the intervention.
We grade this compound and we sell it. The grade is set against our published criteria before any stocking decision and is not adjusted because it is in the catalogue.
read the full evidence →// specification
| full name | Orexin A (hypocretin-1), the 33-residue amidated neuropeptide processed from human prepro-orexin (HCRT) |
| cas | 205599-75-3 |
| formula | C152H243N47O44S4 |
| molar mass | 3561.1 g/mol |
| purity | ≥ 98% HPLC |
| form | lyophilised powder, sealed vial |
| storage | Lyophilised powder is stored desiccated at -20 °C and protected from light. Once reconstituted, laboratory practice is refrigeration at 2-8 °C for short-term use, or aliquoting and freezing to avoid repeated freeze-thaw cycles. Handling information only; this material has no approved human use. |
| solubility | Short hydrophilic peptide, readily soluble in sterile or bacteriostatic water and in dilute aqueous buffer. Lot-specific solubility is stated on the certificate of analysis. |
| sequence | pGlu-PLPDCCRQKTCSCRLYELLHGAGNHAAGILTL-NH2 (33 aa; N-terminal pyroglutamate, C-terminal leucinamide, disulfide bridges Cys6–Cys12 and Cys7–Cys14; residues 34–66 of human prepro-orexin, UniProt O43612) |
// select size
crypto payment · research use only · not for human consumption
// others in Cognitive