mk-677
GH AXIS · GHS-R1a AGONIST · NON-PEPTIDE · ORAL DAILY
also: ibutamoren · MK-0677 · L-163,191
MK-677 is an orally active non-peptide agonist of the ghrelin receptor (GHS-R1a) that raises pulsatile growth hormone and IGF-1 into the young-adult range in older people. It has never been approved anywhere, and a phase 2b hip-fracture trial was terminated early for a congestive heart failure imbalance.
// our evidence grade — unedited
It has the longest controlled human exposure of any compound here, a two-year randomised trial with 12-month primary analysis, but the efficacy is confined to fat-free mass with no functional benefit and it carries a concrete cardiac safety signal that ended a trial early.
We grade this compound and we sell it. The grade is set against our published criteria before any stocking decision and is not adjusted because it is in the catalogue.
read the full evidence →// specification
| full name | Ibutamoren mesylate, a non-peptide growth hormone secretagogue receptor agonist |
| cas | 159634-47-6 |
| formula | C27H36N4O5S |
| molar mass | 528.66 g/mol |
| purity | ≥ 98% HPLC |
| form | research solution |
| storage | Ibutamoren mesylate powder is stable for approximately 4 years at -20°C per FDA's review; laboratory stocks are kept desiccated, sealed and protected from light and moisture. Aqueous or DMSO stock solutions are aliquoted and frozen at -20°C or below to avoid freeze-thaw cycles. |
| solubility | Unlike the peptides in this class MK-677 is a small molecule with high aqueous solubility, reported at 92 mg/mL in both water and ethanol; DMSO is the usual solvent for concentrated laboratory stock solutions. |
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crypto payment · research use only · not for human consumption
// others in Growth Hormone