humanin
MITOCHONDRIAL-DERIVED · 24 AA · mtDNA-ENCODED · PRECLINICAL ONLY
also: HN · MT-RNR2 peptide · HNG (S14G-humanin analogue)
Humanin is a 24-amino-acid peptide encoded by an open reading frame within the mitochondrial 16S rRNA gene MT-RNR2, identified in 2001 as a rescue factor that protected neurons from familial Alzheimer's disease insults. Its cytoprotective biology is well characterised in cells and rodents, but the published human literature appears to be descriptive rather than interventional.
// our evidence grade — unedited
Humanin has an unusually deep, independently replicated mechanistic literature spanning twenty-five years and a defined set of receptors and binding partners, but no published interventional human trial of administered humanin exists.
We grade this compound and we sell it. The grade is set against our published criteria before any stocking decision and is not adjusted because it is in the catalogue.
read the full evidence →// specification
| full name | Humanin (MT-RNR2-encoded mitochondrial-derived peptide) |
| formula | C119H204N34O32S2 |
| molar mass | 2687.3 g/mol |
| purity | ≥ 99% HPLC |
| form | lyophilised powder, sealed vial |
| storage | Supplied as a lyophilised powder; research peptide is generally stored desiccated at -20 °C and protected from light. |
| solubility | Less water-soluble than shorter polar peptides because of the internal leucine-rich hydrophobic stretch; laboratory handling generally requires an organic co-solvent or dilute aqueous acid, and the single cysteine makes it sensitive to oxidation. |
| sequence | MAPRGFSCLLLLTSEIDLPVKRRA |
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crypto payment · research use only · not for human consumption
// others in Growth Hormone