follistatin-344
ACTIVIN/MYOSTATIN ANTAGONIST · 344 AA PRECURSOR · GLYCOPROTEIN
also: FS-344 · FST344 · follistatin 344
FST344 is the 344-residue precursor transcript of human follistatin, a secreted glycoprotein that binds and neutralises activin A and myostatin; after cleavage of its signal peptide it yields the mature FS-315 form. The only human data are two small open-label AAV1 gene-therapy trials in Becker muscular dystrophy and sporadic inclusion body myositis, in which the FST344 gene — not a protein product — was injected into quadriceps muscle.
// our evidence grade — unedited
Every human datapoint attached to this name comes from AAV1-delivered FST344 complementary DNA injected into skeletal muscle in two open-label, unblinded, six-patient gene-therapy trials — not from administering a follistatin protein — so the injectable product sold as 'Follistatin-344' has effectively zero human evidence, on top of an unresolved oncology signal in the activin/follistatin axis and a molecule that cannot credibly be supplied by standard peptide synthesis.
We grade this compound and we sell it. The grade is set against our published criteria before any stocking decision and is not adjusted because it is in the catalogue.
read the full evidence →// specification
| full name | Follistatin isoform FST344 (344-residue precursor of the secreted FS-315 glycoprotein) |
| molar mass | 38007 g/mol |
| purity | ≥ 95% (SDS-PAGE) |
| form | lyophilised powder, sealed vial |
| storage | Recombinant protein: stored lyophilised at -20 °C to -80 °C, desiccated and protected from light. Reconstituted solution is aliquoted and held at -80 °C, with freeze-thaw cycles avoided because the folded protein aggregates readily. Handling information only. |
| solubility | Reconstituted in sterile buffer; carrier protein is commonly added in laboratory use to reduce adsorption losses. |
// select size
crypto payment · research use only · not for human consumption
// others in Growth Hormone