colivelin
ADNF-HUMANIN HYBRID · STAT3/CaMKIV AGONIST · PRECLINICAL ONLY
also: CLN · ADNF-9-AGA-(C8R)HNG17 · activity-dependent neurotrophic factor-humanin hybrid peptide
Colivelin is a 26-amino-acid synthetic hybrid peptide created in 2005 at Keio University by Tomohiro Chiba, Ikuo Nishimoto and Masaaki Matsuoka, joining the neurotrophic nonapeptide ADNF-9 to the potent humanin analogue AGA-(C8R)HNG17. In neuronal cultures and transgenic mouse models of Alzheimer's disease and ALS it suppressed neuronal death at femtomolar concentrations, acting through CaMKIV and STAT3. It has never entered human testing, and is today used mainly as a laboratory STAT3-activating reagent rather than as a drug candidate.
// our evidence grade — unedited
A ClinicalTrials.gov query for colivelin returns totalCount 0 - the compound has never been administered to a human being in a registered trial, and no clinical study of any design exists twenty years after its 2005 description. Every efficacy claim rests on rodent and cell-culture work from a small number of groups.
We grade this compound and we sell it. The grade is set against our published criteria before any stocking decision and is not adjusted because it is in the catalogue.
read the full evidence →// specification
| full name | Colivelin (ADNF-9 fused to the humanin analogue AGA-(C8R)HNG17) |
| cas | 867021-83-8 |
| formula | C119H206N32O35 |
| molar mass | 2645.1 g/mol |
| purity | ≥ 98% HPLC |
| form | lyophilised powder, sealed vial |
| storage | Lyophilised powder is stored desiccated at -20 °C, protected from light and moisture. Reconstituted solution is aliquoted and frozen for anything beyond short-term use. Handling information only; this compound has never been administered to a human. |
| solubility | Soluble in sterile water and aqueous buffer; DMSO is sometimes used for concentrated stock preparation in cell-culture work. |
| sequence | SALLRSIPAPAGASRLLLLTGEIDLP |
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crypto payment · research use only · not for human consumption
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