b7-33
RELAXIN ANALOGUE · BIASED RXFP1 AGONIST · PRECLINICAL ONLY
also: B7-33 peptide · single-chain relaxin mimetic · H2 relaxin B-chain analogue B7-33
B7-33 is a 27-residue linear peptide corresponding to residues 7-29 of the human relaxin-2 (H2 relaxin) B-chain with the two cysteines replaced by serine and a C-terminal KRSL extension, developed at the University of Melbourne / Florey Institute by Hossain, Bathgate, Samuel and colleagues. It is a functionally selective (biased) agonist of the relaxin receptor RXFP1, activating pERK1/2 with only weak cAMP signalling, and reduced fibrosis in rodent cardiac and airway disease models. No human trial of B7-33 has ever been registered or published.
// our evidence grade — unedited
B7-33 has never been tested in humans: searches of ClinicalTrials.gov and the EU Clinical Trials Register return zero registered studies of any phase, so the entire evidence base is rodent and in vitro. The full-length hormone it mimics failed its definitive 6,545-patient phase 3 (RELAX-AHF-2, both primary endpoints missed) and was refused marketing authorisation by the EMA.
We grade this compound and we sell it. The grade is set against our published criteria before any stocking decision and is not adjusted because it is in the catalogue.
read the full evidence →// specification
| full name | B7-33 (single-chain analogue of the human relaxin-2 / H2 relaxin B-chain) |
| cas | 1818415-56-3 |
| formula | C131H228N40O37S |
| molar mass | 2987.5 g/mol |
| purity | ≥ 98% HPLC |
| form | lyophilised powder, sealed vial |
| storage | Lyophilised powder is stored desiccated at -20 °C and protected from light. Reconstituted solution is held at 2-8 °C for short-term laboratory use or aliquoted and frozen; the peptide is linear and disulfide-free, so aggregation on freeze-thaw is less of a concern than for the parent two-chain hormone. Handling information only. |
| solubility | Soluble in sterile or bacteriostatic water; the cysteine-to-serine substitutions remove disulfide-driven aggregation, which is why this analogue exists at all. |
| sequence | VIKLSGRELVRAQIAISGMSTWSKRSL |
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crypto payment · research use only · not for human consumption
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